Multicomponent reactions (MCR) have emerged as a versatile and power full methodology for the synthesis of complex molecules whit often biologically relevant scaffold structures. Since fewer chemicals and solvents, as well as less energy are required, these reactions represent an environmentally- friendly alternative to standard synthetic protocols in organic chemistry and drug discovery.
Edited by leading experts and with a list of authors reading like a “who’s who” in MCR chemistry, this timely work focuses on the latest advances in the field. In addition to chapters classified according to the key substrate used, radical and frequently applied metal- catalyzed MCRs; it also covers recently developed catalytic enantioselective variants as well as applications in the synthesis of heterocyclic molecules and macrocycles.
A comprehensive overview foe every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.
List of contributors
Preface
1 General introduction to MCRs: past, present, and future
2 Discovery of MCRs
3 Aryne- based multicomponent reactions
4 Ugi- similes and passerine- smiles couplings
5 1,3- Dicarbonyls in Multicomponent reactions
6 Functionalization of heterocycles by MCRs
7 Diazoacetate and related metal- stabilized carbene species in MCRs
8 Metal- catalyzed multicomponent synthesis of heterocycles
9 Macrocycles from multicomponent reactions
10 Multicomponent reactions under oxidative conditions
11 Allenes in multicomponent synthesis of heterocycles
12 Alkynes in multicomponent synthesis of heterocycles
13 Anhydride- based multicomponent reactions
14 Free- radical multicomponent processes
15 Chiral phosphoric acid- catalyzed asymmetric multicomponent
Index
